Senior Microsoft Systems Engineer

Boston, MA, USA Req #242
Friday, March 15, 2024
Who We Are:  
Xenon Pharmaceuticals (NASDAQ:XENE) is a neuroscience-focused biopharmaceutical company committed to discovering, developing, and commercializing innovative therapeutics to improve the lives of people living with neurological and psychiatric disorders. We are looking for great people who thrive in a respectful, collaborative, inclusive, and productive culture to join the Xenon team. 
What We Do: 
We are advancing an exciting product pipeline to address indications with high unmet medical need, including epilepsy and depression. Our flagship azetukalner program represents the most advanced potassium channel modulator in clinical development for multiple indications. Building upon the positive results and compelling data from our Phase 2b “X-TOLE” study in adult patients with focal epilepsy, our Phase 3 epilepsy program includes multiple clinical trials evaluating azetukalner in patients with focal onset seizures and primary generalized tonic-clonic seizures. In 2024, we are planning to initiate a Phase 3 azetukalner program in major depressive disorder, based on topline data from our Phase 2 “X-NOVA” clinical trial. In addition, we are proud of the leading-edge science coming out of our discovery labs, including early-stage research programs that leverage our extensive ion channel expertise and drug discovery capabilities to identify validated drug targets and develop new product candidates. Backed by a strong balance sheet to support our growth plans, we continue to build a fully integrated, premier neuroscience company with strong discovery, clinical development, corporate, and commercial operations. 

About the Role:

We are seeking a Senior Microsoft Systems Engineer to join our team. This role will serve as the technical lead and strategist for the IT End User Computing Team. The team utilizes Microsoft Intune to manage devices and offers a variety of productivity tools centered on the Microsoft 365 platform. The Senior Microsoft Systems Engineer will serve as the technical system owner for these platforms as well as others related to productivity, messaging, collaboration, and workplace services. The successful candidate will also play a hands-on role with technical escalations and will often interact with vendor support and consultants on behalf of the team. Near-term projects include completing the transition from SCCM/ECM to Intune, automating the computer imaging process with Autopilot, evaluating Autopatch and 3rd party patching, and planning the transition to Windows 12. During this period of rapid growth and evolution, this role may be assigned additional responsibilities (beyond Microsoft platforms and the core responsibilities described above) based on company needs, the individual’s experience and expertise, and the availability of resources within IT.

This position reports to the Director, End User Computing and can be located in the Vancouver area, BC, Canada or Boston area, MA, USA. The level of the position will be commensurate with the candidate’s education and industry experience. 


  • Serve as the technical system owner for the Microsoft Intune Endpoint Management platform and the Microsoft 365 platform (including Office Apps, Exchange, SharePoint, OneDrive, and Teams).
  • Serve as a domain administrator for Active Directory. Partner with the Infrastructure Team on implementing Group Policy and Conditional Access Policies in Intune.
  • Evaluate the latest developments and releases from Microsoft and other productivity solutions (e.g. Copilot). Test and evaluate Beta/Preview offerings to determine fit for use. Promote adoption of relevant capabilities and features within Microsoft 365 (e.g. SharePoint, Teams, Productivity Apps, etc.). 
  • Develop a multi-year roadmap for endpoint management platforms and productivity solutions.
  • Design, plan, configure, document, deploy, and support new messaging, secure file collaboration, video conferencing, productivity solutions, and endpoint management automation.
  • Assess endpoint security solutions, improve vulnerability management, and assist with incident response.
  • Configure and deploy conditional access policies, configuration profiles, remediations, scripts, and software packages to properly manage endpoint devices.
  • Serve as the technical escalation point for the End User Computing Team in support of endpoint systems and platforms including Laptops, Mobile Devices, Lab PCs, Microsoft Teams Rooms Yealink A/V, Multi-Function Printers, and related tools. Investigate problems and implement changes as needed.
  • Leverage the Power Platform to develop no/low-code applications to automate routine processes.
  • Maintain the end-user and lab computing environments to stay current with patching and policy compliance, assessing reports, and implementing remediations.
  • Maintain the tools and processes required for productive and secure collaboration with external parties.
  • Responsible for producing asset management inventories, compliance reports, project documentation, and system architecture diagrams using Visio.
  • Develop and maintain strong relationships with technical system owners across IT and the company.
  • Manage vendors and external resources per their contracted terms and conditions in the context of both project delivery and ongoing operations to maximize return on investment for Xenon.
  • Contribute documentation to the knowledge management process for both end user articles and technical instructions for IT administrators.
  • Ensure compliance with internal processes and standards to support compliance with relevant regulations (e.g. GxP, SOX, privacy). 
  • Develop and propose short- and long-term objectives and project plans for the function in accordance with overall Company strategies and plans.
  • Act in accordance with Company policies, including, for example, the Code of Business Conduct and Ethics and ensure policies are understood and followed by direct reports, if any.
  • Provide 24x7 support as needed for emergency situations and planned maintenance activities.
  • Other duties as assigned.


  • Minimum undergraduate degree in Computer Science or related discipline and at least 10 years of progressive information technology experience. Microsoft, ITIL, and associated IT certifications are a plus.
  • Experience in highly regulated industries requiring proficiency working through audit, process, and compliance requirements is preferred. Experience with computer system validation to support a commercial organization in the life sciences industries is preferred.
  • Deep technical experience with Windows 10/11/Server OS, AD, GPO, Azure AD/Entra ID, Microsoft 365 (Exchange, Teams, SharePoint, OneDrive etc.), Intune, SCCM/ECM, Power Platform, Teams Rooms, Print Services, VDI, mobile devices, laboratory computers, and endpoint security (Defender & Crowdstrike).
  • Experience with email security technologies and protocols such as Microsoft Defender, KnowBe4, SMTP, SPF, DKIM, DMARC, TLS, S/MIME, email encryption, and digital signatures.
  • Understanding of TCP/IP, DNS, DHCP, VPN, and other networking concepts.
  • Experience with programming languages, PowerShell, Python, Graph API, and the Power Platform.
  • Demonstrated ability to serve as the technical lead and key contributor for cross-functional projects. Successful track record in balancing several objectives simultaneously against a multi-year roadmap.
  • Strong experience in IT operations including ITIL/ITSM processes, with specific emphasis on Major Incident Management, Problem Management, and Change Management.
  • Effective problem solving, with an emphasis on diagnosing and resolving root causes, and on building and supporting robust solutions. Experience operating as a technical escalation point for Service Desk MSPs.
  • Excellent written and verbal communication skills with the ability to explain highly technical information in a concise and effective manner to an audience of varying technical aptitude.
  • Strong interpersonal skills and a customer service mindset. Proactive in anticipating user pain points, extracting business requirements, and developing technical solutions and automation to improve services.
  • Demonstrated experience as a technical mentor with the ability to lead both end user and admin training.
  • Ability to work independently, as a team member, and across the organization at any level.
  • Ability to work flexibly in a fast-paced environment with a strong work ethic and positive attitude.

The base salary range for this role is $142,200 to $179,800 USD; we will consider above this range for exceptional candidates. Base salary is determined by a combination of factors including, but not limited to, education and other qualifications, years of relevant experience, and internal equity. 

Our Total Rewards program includes base salary, target bonus, and stock options, as well as a full range of benefits including medical, dental, vision, short-& long-term disability, accidental death & dismemberment, and life insurance programs, Employee Assistance Program, travel insurance, and retirement savings programs with company matching contributions.

Xenon encourages time to rest and re-charge through vacation, personal days, sick days, and an end-of-year company shutdown. Xenon highly values employee development and has an expanding Training, Learning & Development program, including a Tuition Assistance program for advanced degrees.
US positions only: Xenon Pharmaceuticals USA Inc. participates in the E-Verify program in all states in which we hire. Learn more about the E-Verify program here 

To apply for this position, click Apply Now to complete the application. We thank all applicants for their interest; however, due to the volume of applicants, only those chosen for interview will be contacted.